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  1. In Vitro Maturation: IVM

    You need IVF. But, you hate the idea of taking lots of drugs that push your hormone levels into the stratosphere. You are concerned that really high estrogen levels may be unhealthy and doctors just don’t know it yet. You really don’t want to be prodded for multiple laboratory tests.  You have things to do; places to go.  You would really like something easier than IVF.

    You may be a candidate for a new approach at Brown Fertility for getting pregnant: IVM or in vitro maturation. The eggs a woman is born with are kept in an immature state, meaning a sperm cannot fertilize them, until ovulation.  Most medications used in IVF are intended to enable the patient to develop multiple eggs that are mature.  It is now possible to take eggs from a woman’s ovaries and mature them in the laboratory.  This means it is not necessary to treat women with high doses of stimulating hormones for two weeks before retrieving eggs.  Technically, eggs can be retrieved at any time. These eggs can be matured in the laboratory (IVM).   They are then capable of being fertilized and embryos can be created using the normal IVF tools.

    This was always the dream of the creators of IVF, but it proved to be more difficult than IVF. It was not until 1991, that the first birth occurred using IVM, by Dr. Cha in Korea.  He obtained a donor egg from a woman during her Caesarian Section and used it to help a couple have a baby.  Once IVM was shown to be possible, physicians and scientists in IVF programs throughout the world began working on the details of how best to use this technology.  Several thousand babies have now been born using IVM, but there is no uniform agreement on how to best use IVM techniques in humans.

    Although IVM is practiced in centers throughout Europe and Asia, it has limited availability in the United States. IVM is easier for the patient than IVF, but is harder on the physician and laboratory.  Dr. Bruce Rose has one of the larger experiences with IVM in the United States, having performed more than 200 IVM cycles and published a half dozen papers on related topics.  He has recently joined Brown Fertility to bring this new technique to the Jacksonville area.

    IVM is not a replacement for IVF, but it is a more gentle approach to high tech reproduction than IVF, which in selected patients has almost as high a pregnancy rate as IVF. Traditionally, physicians treat medical problems by using the least invasive, lowest side effect treatment first and then moving on to more aggressive treatments if they are needed.  This is the way we should view the relationship between IVM and IVF.  Patients at high risk for significant side effects with IVF, could use the more simple, safer IVM approach; and if that fails them, then turn to IVF.

    The best candidates for IVM are those patients with a large number of small cysts or antral follicles (2-10 mm) in their ovaries. These patients are at highest risk for the most severe common complication of IVF- ovarian hyperstimulation syndrome OHSS.  Even without development of OHSS, patients with a large number of resting follicles in their ovaries will experience significant bloating and abdominal discomfort for several weeks after IVF as the ovaries and the pelvis return to normal.  Patients with polycystic ovaries are the candidates most likely to benefit from IVM, but most young women will also have a large number of small follicles in their ovaries.  A subset of older women not meeting the clinical criteria of PCOS  will also be good candidates.  The only way to determine who is a good candidate is to perform a transvaginal ultrasound and evaluate the ovaries.

    IVM should still be viewed as an experimental procedure.  Our present objective is to find the best way to apply it so that our patients achieve a success rate similar to our IVF success rate without the risk of IVF like side effects.  The cost of this procedure is lower than IVF in that limited medications are used and IVF medication costs usually constitute about 40% of the cost to undertake IVF.  Laboratory and physician costs are similar.  Except for egg harvesting (the same setting as IVF), IVM is minimally disruptive to our patients.  It even works for patients who either struggle to ovulate or fail to ovulate with clomid, femara, or gonadotropins.  We have performed IVM in patients a week before their getting married or while breast feeding.  Brown Fertility now offers an effective, more natural alternative to conventional IVF.

     

    About Brown Fertility: With more than 30 years of combined experience and the management of more than 7,000 IVF cycles, Dr. Samuel E. Brown, Dr. Rafael A. Cabrera and Dr. Bruce Rose are dedicated to Conceiving Miracles™. Brown Fertility offers a fully comprehensive array of fertility treatments, including in vitro fertilization, egg donation and artificial insemination and is home to Florida’s most state-of-the-art IVF center, which produces some of the highest pregnancy rates in the country. Brown Fertility has earned a reputation for not only producing excellent outcomes and offering affordable treatment options, but also for providing patients with the one-on-one attention and the compassionate care they deserve. Visit www.BrownFertility.com for more information.

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    Media Contact:

    Nicole Haggerty, Director of Marketing

    nahaggerty@brownfertility.com

    904.260.0352

  2. Brown Fertility Announces First IVM Pregnancy

    JACKSONVILLE, FL (August 1, 2017) – Dr. Bruce Rose, a reproductive endocrinologist with Brown Fertility is pleased to announce their first IVM pregnancy.

    IVM is a ground breaking fertility treatment that is a more gentle approach to high tech reproduction than IVF, which in selected patients has almost as high a pregnancy rate as IVF. Most medications used with IVF are intended to enable the patient to develop multiple eggs that are mature. It is now possible to take eggs from a woman’s ovaries and mature them in the laboratory.

    This means it is not necessary to treat women with high doses of stimulating hormones for two weeks before retrieving eggs. Technically, eggs can be retrieved at any time. These eggs can be matured in the laboratory (IVM), where they are then capable of being fertilized and embryos can be created using the normal IVF tools.

    “Traditionally, physicians treat medical problems by using the least invasive, lowest side effect treatment first and then moving on to more aggressive treatments if they are needed.  This is the way we should view the relationship between IVM and IVF.  Patients at high risk for significant side effects with IVF could use the simpler, safer IVM approach; and if that fails them, then turn to IVF”, stated Dr. Bruce Rose.

    Dr. Bruce Rose has one of the larger experiences with IVM in the United States, having performed more than 200 IVM cycles and published a half dozen papers on related topics. He has recently joined Brown Fertility to bring this new technique to the Jacksonville area.

    About Brown Fertility: With more than 30 years of combined experience and the management of more than 7,000 IVF cycles, Dr. Samuel E. Brown, Dr. Rafael A. Cabrera and Dr. Bruce Rose are dedicated to Conceiving Miracles™. Brown Fertility offers a fully comprehensive array of fertility treatments, including in vitro fertilization, egg donation and artificial insemination and is home to Florida’s most state-of-the-art IVF center, which produces some of the highest pregnancy rates in the country. Brown Fertility has earned a reputation for not only producing excellent outcomes and offering affordable treatment options, but also for providing patients with the one-on-one attention and the compassionate care they deserve. Visit www.BrownFertility.com for more information.

    ###

    Media Contact:

    Nicole Haggerty, Director of Marketing

    nahaggerty@brownfertility.com

    904.260.0352

  3. Hope and Life Through Egg and Embryo Donation

    Women with diminished ovarian reserve, poor egg quality, advanced maternal age, genetic concerns or premature ovarian failure are encouraged to explore the options of our egg and embryo donation programs when trying to conceive.

    Egg Donation Program at Brown Fertility

    Egg donation, also known as ovum or oocyte donation, is a fertility treatment option for women whose eggs are unable to achieve a successful pregnancy due to advanced reproductive age, genetic abnormalities, previous surgeries and/or other conditions. Brown Fertility’s respected and experienced Egg Donation Team is known for its focus and success in matching the highest quality donors with recipients, while providing compassionate care throughout the matching and treatment process. Thanks to our team, hundreds of individuals and couples have built their families using donor eggs.

    The donors we recruit are healthy women between the ages of 18 and 34 with no known genetic or sexually transmitted diseases. By having an onsite donor program, recipients can avoid the costs associated with using a donor agency.  The process begins with potential donors submitting applications to our practice. The applicants are then contacted to complete an initial FDA screening, and if eligible, they will complete an extensive questionnaire, detailing individual family history, physical characteristics, and general interests.   Potential donors are then interviewed in person by our Third Party Nurse and one of our Reproductive Endocrinologists.  Those deemed eligible to donate are then screened to ensure a clean bill of health and are required to complete a psychological evaluation confirming they fully understand the donation process.  The potential donors are then entered into our password protected website and will be contacted to begin a cycle upon being chosen by the intended recipient.  We are proud to offer our recipients one of the largest selections of donors in the state of Florida from various racial and ethnic backgrounds.

    Recipients select a donor with our Egg Donation Team and once matched, both the recipient and donor will begin their medication and treatment plan as prescribed by our physicians. The eggs retrieved from the donor will then be fertilized with the recipient partner’s sperm (or donor sperm) via in-vitro fertilization, using a technique called intracytoplasmic sperm injection (ICSI). The fertilized eggs (embryos) are then monitored and transferred to the recipient. Remaining quality embryos are cryopreserved and placed in storage.

    While egg quality deteriorates with age, a woman’s uterus and her ability to carry and deliver a child remains relatively constant. Therefore, egg donation offers a substantially higher chance for the delivery of a healthy baby, even in women of advanced maternal age. Brown Fertility offers some of the highest success rates for donor cycles in the country.

    Embryo Donation Program at Brown Fertility

    Another option available to patients who require the use of donor egg and/or donor sperm is our Embryo Donation Program.  We invite these patients to explore our program as it is an opportunity for them to achieve the dream of conceiving a miracle at a significantly lower cost in comparison to the egg donation program.  The program consists of donated embryos from our previous patients who have gone through IVF and have completed their family, but have cryopreserved embryos that they have chosen to donate.  These embryos have been previously screened when the donating couple went through the IVF process.  Intended recipients are provided with demographic information from the donating couple including age, ethnicity, height, weight, hair and eye color, medical and family history.  As with our egg donation program, embryo donation is completely anonymous.  The donating couple will not be given the identity of the recipient couple and vice versa.  In addition, the recipient is required to complete a psychological evaluation just as is required for our egg donation program.  Once matched, the recipient will begin to prepare her body for the embryo transfer.

    We Are Here to Help

    Choosing to participate in Brown Fertility’s egg donation or embryo donation is a big decision, both emotionally and financially.  While these options may not be for everyone, they do provide much needed hope and opportunity to couples who otherwise are not able to conceive a child.  We encourage couples to schedule a consultation to discuss with one of our dedicated and knowledgeable team members.

See what our Patients are Saying About Us View All

“Throughout our journey to conceive, Dr. Brown became so much more than our reproductive endocrinologist. He became our therapist, problem-solver, cheerleader, and—most importantly—our friend.”Greg & Dana