Decades of Research Behind the Care We Provide

At Brown Fertility, our physicians do more than follow advances in reproductive medicine.

They have published research, led clinical studies, taught future physicians, and examined many of the treatment questions patients still face today.

That experience comes into the room with us. It helps us look closely at your history, explain the reason behind a recommendation, and decide whether a familiar approach truly fits your needs.

This is the record behind our care.

90+ Combined years in reproductive medicine
3 Fellowship-trained REI subspecialists
90+ Published works, abstracts, and presentations
20+ Clinical studies as principal or sub-investigator
National Media coverage and academic leadership
Decades of Shared Expertise

Three Physicians, One Shared Standard

Dr. Samuel E. Brown, Dr. Angeline N. Beltsos, and Dr. Bruce I. Rose have followed different paths through reproductive medicine. Their combined experience includes IVF, fertility surgery, clinical research, academic teaching, medical leadership, and the management of thousands of treatment cycles.

Each physician brings a different area of depth to our practice. What connects them is a shared standard: look carefully at the evidence, understand the individual patient, and recommend treatment for a clear medical reason.

Dr. Samuel E. Brown

Samuel E. Brown, MD, HCLD

Reproductive Endocrinologist and Infertility Specialist
Founder and Medical Director, Brown Fertility

Has helped guide more than 30,000 IVF cycles while building a career across fertility care, reproductive surgery, research, and medical education.

Dr. Samuel E. Brown completed his fellowship in reproductive endocrinology and infertility at the Jones Institute for Reproductive Medicine, the program associated with the first IVF birth in the United States.

After completing his fellowship, he began practicing as a reproductive endocrinologist in 2000. He founded Brown Fertility in 2009 and has since helped build a practice serving patients across Florida and Georgia.

Dr. Brown's work extends beyond the fertility clinic. His academic appointments have included Mayo Clinic Jacksonville and the University of Florida College of Medicine, where he directed the Division of Reproductive Endocrinology and Infertility.

His research has addressed questions involving IVF, ovarian stimulation, intrauterine insemination, uterine evaluation, fertility preservation before cancer treatment, egg and embryo freezing, endometrial function, in vitro maturation, and premature ovarian insufficiency.

MTHFR and Pregnancy Loss Robotic and Laparoscopic Surgery Endometriosis IVF and IVM Fertility Preservation Uterine Evaluation

Flagship Publications

  • Rose BI, Brown SE. "Genetically Modified Babies and a First Application of CRISPR-Cas9." Obstetrics & Gynecology, 2019.
  • Brown SE, Toner JP, and colleagues. "Vaginal Misoprostol Enhances Intrauterine Insemination." Human Reproduction, 2001.
  • Rose BI, Nguyen K, Brown SE. "The Effect of IVM Protocol Changes on Measures of Oocyte and Embryo Competence." Reproductive Medicine, 2023.
Full Publication Record 15 peer-reviewed works · 5 posters · 9 abstracts
Peer-Reviewed Publications
  1. Rose BI, Nguyen K, Brown SE. "The Effect of In Vitro Maturation Protocol Changes on Measures of Oocyte and Embryo Competence." Reproductive Medicine, 2023.
  2. Rose BI, Brown SE. "A Review of the Physiology Behind Letrozole Applications in Infertility: Are Current Protocols Optimal?" Journal of Assisted Reproduction and Genetics, 2020.
  3. Rose BI, Brown SE. "An Explanation of the Mechanisms Underlying Fragile X-Associated Premature Ovarian Insufficiency." Journal of Assisted Reproduction and Genetics, 2020.
  4. Rose BI, Brown SE. "Genetically Modified Babies and a First Application of CRISPR-Cas9." Obstetrics & Gynecology, 2019.
  5. Rose BI, Brown SE. "In Vitro Maturation: A Kinder, Gentler, More Natural, and Less Expensive Way to Undertake IVF." Northeast Florida Medicine, 2017.
  6. Yang D, Brown SE, and colleagues. "Live Birth After the Transfer of Human Embryos Developed From Cryopreserved Oocytes Harvested Before Cancer Treatment." Fertility and Sterility, 2007.
  7. Brown SE. "Osteoporosis: Snap, Crackle & Pop Some Pills." Northeast Florida Medicine, 2006.
  8. Kerdelhue B, Brown S, and colleagues. "Timing of Initiation of the Preovulatory Luteinizing Hormone Surge and Its Relationship With the Circadian Rhythm in the Human." Neuroendocrinology, 2002.
  9. Brown SE, Toner JP, and colleagues. "Vaginal Misoprostol Enhances Intrauterine Insemination." Human Reproduction, 2001.
  10. Toner J, de Ziegler D, Brown SE, and colleagues. "High Rates of Cramping With Misoprostol Administration for Intrauterine Insemination." Human Reproduction, 2001.
  11. Schnorr JA, Brown SE, and colleagues. "Impact of Intracytoplasmic Sperm Injection on Embryo Cryopreservation and Clinical Outcome." Fertility and Sterility, 2001.
  12. Brown SE, Coddington CC, and colleagues. "Evaluation of Outpatient Hysteroscopy, Saline Infusion Hysterosonography and Hysterosalpingography in Infertile Women." Fertility and Sterility, 2000.
  13. Brown SE, Mandelin E, and colleagues. "Endometrial Glycodelin-A Expression in the Luteal Phase of Stimulated Ovarian Cycles." Fertility and Sterility, 2000.
  14. Brown SE, Mandelin E, and colleagues. "Histochemical Localization of Endometrial Insulin-Like Growth Factor Binding Protein 1 and 3 During the Luteal Phase in Controlled Ovarian Hyperstimulation Cycles." Fertility and Sterility, 2000.
  15. Brown S. "Ectopic Pregnancy and Tubal Physiology." Resident and Staff Physician Journal, 1996.
Posters and Abstracts

Dr. Brown has presented or contributed research at meetings of the American Society for Reproductive Medicine, the International Federation of Fertility Societies, the European Society of Human Reproduction and Embryology, and the Society for Gynecologic Investigation.

Topics include ovarian stimulation, intrauterine insemination, intracytoplasmic sperm injection, egg donation, embryo cryopreservation, myomectomy, and fertility treatment outcomes.

Dr. Angeline N. Beltsos

Angeline N. Beltsos, MD

Reproductive Endocrinologist and Infertility Specialist
Physician, Researcher, and Fertility Practice Leader

Brings more than 30 years of fertility experience, including over 15,000 embryo transfers, 12,000 egg retrievals, and participation in more than 20 clinical studies.

Dr. Angeline N. Beltsos completed her fellowship in reproductive endocrinology and infertility at Washington University in St. Louis. Since entering practice in 1997, she has cared for thousands of patients while also leading fertility practices, clinical studies, and professional education.

She founded Vios Fertility Institute and has held senior medical and executive roles with Fertility Centers of Illinois and Kindbody. She is also the founder and executive chair of the Midwest Reproductive Symposium International.

The annual symposium brings fertility physicians, embryologists, nurses, researchers, mental health professionals, and other specialists together to discuss current work in reproductive medicine.

Dr. Beltsos's research has focused on many of the decisions patients face during IVF, including ovarian stimulation, egg retrieval, embryo transfer, progesterone support, egg freezing, genetic testing, PCOS, and factors that may influence treatment response.

IVF Treatment Planning Egg Retrieval Embryo Transfer Egg Freezing Ovarian Stimulation PCOS Genetic Testing

Flagship Publications

  • Feinberg EC, Beltsos AN, and colleagues. "Endometrin as Luteal Phase Support in Assisted Reproduction." Fertility and Sterility, 2013.
  • Boostanfar R, Shapiro B, Levy M, Beltsos AN, and colleagues. "Non-Inferiority of Corifollitropin Alfa Compared With Recombinant FSH in Older IVF Patients." Fertility and Sterility, 2015.
  • Jungheim ES, Ryan GL, Levens ED, Beltsos AN, Odem RR, and colleagues. "Embryo Transfer Practices in the United States." Fertility and Sterility, 2010.
Full Research Record 12 peer-reviewed manuscripts · 20+ clinical studies
Peer-Reviewed Publications
  1. Boostanfar R, Shapiro B, Levy M, Beltsos AN, and colleagues. "Non-Inferiority of Corifollitropin Alfa Compared With Recombinant FSH in Older IVF Patients." Fertility and Sterility, 2015.
  2. Beltsos AN, Sanchez MD, Doody KJ, and colleagues. "Patients' Administration Preferences: Progesterone Vaginal Insert Compared to Intramuscular Progesterone for Luteal Phase Support." Reproductive Health, 2014.
  3. Feinberg EC, Beltsos AN, Nicolaou E, and colleagues. "Endometrin as Luteal Phase Support in Assisted Reproduction." Fertility and Sterility, 2013.
  4. Omurtag K, Grindler NM, Roehl KA, Bates GW, Beltsos AN, and colleagues. "How Members of SREI and SRS Evaluate, Define, and Manage Hydrosalpinges." Fertility and Sterility, 2012.
  5. Jungheim ES, Ryan GL, Levens ED, Beltsos AN, Odem RR, and colleagues. "Embryo Transfer Practices in the United States: A Survey of SART-Registered Clinics." Fertility and Sterility, 2010.
  6. Martin-Johnston MK, Uhler ML, Grotjan HE, Beltsos AN, and colleagues. "Lower Chance of Pregnancy With Repeated Cycles of In Vitro Fertilization." Journal of Reproductive Medicine, 2009.
  7. Sneed ML, Uhler ML, Grotjan HE, Beltsos AN, and colleagues. "Body Mass Index: Impact on IVF Success Appears Age-Related." Human Reproduction, 2008.
  8. Martin-Johnston M, Beltsos AN, Grotjan HE, Uhler ML. "Adding Human Menopausal Gonadotrophin to Antagonist Protocols: Is There a Benefit?" Reproductive BioMedicine Online, 2007.
  9. Uhler ML, Beltsos AN, Grotjan HE, and colleagues. "Age-Matched Comparison of Recombinant and Urinary hCG for Final Follicular Maturation." Reproductive BioMedicine Online, 2006.
  10. Jablonka-Shariff A, Ravi S, Beltsos AN, and colleagues. "Abnormal Estrous Cyclicity After Disruption of Endothelial and Inducible Nitric Oxide Synthase in Mice." Biology of Reproduction, 1999.
  11. Beltsos AN, Odem RR. "Ovulation Induction and Ovarian Cancer." Seminars in Reproductive Endocrinology, 1996.
  12. Beltsos AN, Fisher S, Uhler ML, and colleagues. "The Relationship of the Postcoital Test and Semen Characteristics to Pregnancy Rates in 200 Presumed Fertile Couples." International Journal of Fertility, 1996.
Clinical-Study Experience

Dr. Beltsos has served as a principal investigator or sub-investigator in studies involving:

  • Ovarian stimulation medications and IVF protocols
  • IVF treatment for patients with PCOS
  • Progesterone support after embryo transfer
  • Egg vitrification and warming
  • Frozen embryo transfer outcomes
  • Biomarkers associated with implantation
  • Preimplantation genetic testing
  • Noninvasive assessment of egg development
  • IVF treatment for patients between ages 35 and 42
  • Patient support during fertility treatment

These studies are part of Dr. Beltsos's professional record. They should not be understood as current enrollment opportunities at Brown Fertility.

Presentations and Posters

Dr. Beltsos has presented or contributed research at meetings of the American Society for Reproductive Medicine, the Society for Reproductive Investigation, the Pacific Coast Reproductive Society, and the Midwest Reproductive Symposium International.

Her presentation topics include embryo transfer, ovarian reserve, uterine receptivity, reciprocal IVF, oncofertility, vitamin D, genetic screening, IVF protocols for patients over 40, and social media in patient care.

Dr. Bruce I. Rose

Bruce I. Rose, MD, PhD

Reproductive Endocrinologist and Infertility Specialist
Physician, Researcher, and Published Author

Brings more than 30 years of reproductive medicine experience and a research record that includes more than 50 medical and scientific publications.

Before entering medicine, Dr. Bruce I. Rose earned a PhD in mathematics and taught at the University of Notre Dame. He later completed medical school at the University of Miami and remained there for his fellowship in reproductive endocrinology and infertility.

His background in mathematics and medicine has shaped the way he approaches fertility research. His work looks closely at treatment methods, laboratory measures, and the factors that may influence egg, embryo, and implantation outcomes.

A significant part of Dr. Rose's research has focused on in vitro maturation, or IVM. With IVM, eggs are collected before they are fully mature and complete part of the maturation process in the laboratory.

His work has examined egg retrieval, egg maturation, embryo development, endometrial preparation, and ways to reduce the risk of severe ovarian hyperstimulation.

In Vitro Maturation IVF Laboratory Review Egg and Embryo Development Implantation Ovarian Hyperstimulation PCOS Letrozole

Flagship Publications

  • Rose BI. "Approaches to Oocyte Retrieval for Advanced Reproductive Technology Cycles Planning to Utilize In Vitro Maturation." Journal of Assisted Reproduction and Genetics, 2014.
  • Rose BI, Laky DC, Miller B. "The Case for IVM: Lower Cost and More Patient Friendly." Journal of Reproductive Medicine, 2014.
  • Rose BI. "Avoidance of Severe Ovarian Hyperstimulation With IVM Treatment." In Development of In Vitro Maturation for Human Oocytes, Springer, 2017.
Full Research Record 51 peer-reviewed publications · 1 book chapter
Selected Peer-Reviewed Publications
  1. Rose BI, Nguyen K, Brown S. "The Effect of In Vitro Maturation Protocol Changes on Measures of Oocyte and Embryo Competence." Reproductive Medicine, 2023.
  2. Rose BI. "Identifying Women With a Narrow Window of Embryo Implantation Using the Endometrial Receptivity Assay." International Journal of Clinical Obstetrics and Gynaecology, 2022.
  3. Rose BI. "Female Astronauts: Impact of Space Radiation on Menopause." European Journal of Obstetrics, Gynecology, and Reproductive Biology, 2022.
  4. Rose BI, Nguyen K. "The Blastulation Rate as a Metric for an In Vitro Fertilization Laboratory." Gynecology and Obstetrics, 2022.
  5. Rose BI, Brown SE. "A Review of the Physiology Behind Letrozole Applications in Infertility: Are Current Protocols Optimal?" Journal of Assisted Reproduction and Genetics, 2020.
  6. Rose BI, Brown SE. "An Explanation of the Mechanisms Underlying Fragile X-Associated Premature Ovarian Insufficiency." Journal of Assisted Reproduction and Genetics, 2020.
  7. Rose BI, Brown SE. "Genetically Modified Babies and a First Application of CRISPR-Cas9." Obstetrics & Gynecology, 2019.
  8. Rose BI. "In Vitro Maturation: A Tool for Avoiding Severe Ovarian Hyperstimulation Syndrome and Expanding Patient Options." Austin Journal of In Vitro Fertilization, 2017.
  9. Rose BI, Brown SE. "In Vitro Maturation: A Kinder, Gentler, More Natural, and Less Expensive Way to Undertake IVF." Northeast Florida Medicine, 2017.
  10. Rose BI, Rose CS. "The Use of Advanced Reproductive Technologies While Breastfeeding: A Role for In Vitro Maturation." Obstetrics and Gynecology Cases Reviews, 2016.
  11. Rose BI. "The Case for More Active Management of Endometrial Development in IVM." Journal of Reproductive Endocrinology and Infertility, 2015.
  12. Rose BI, Laky DC, Rose SD. "A Comparison of the Use of Clomiphene Citrate and Letrozole in Patients Undergoing IVF With the Objective of Producing Only One or Two Embryos." Facts, Views and Vision in ObGyn, 2015.
  13. Rose BI. "Approaches to Oocyte Retrieval for Advanced Reproductive Technology Cycles Planning to Utilize In Vitro Maturation." Journal of Assisted Reproduction and Genetics, 2014.
  14. Rose BI, Laky DC, Miller B. "The Case for IVM: Lower Cost and More Patient Friendly." Journal of Reproductive Medicine, 2014.
  15. Rose BI. "A New Treatment to Avoid Severe Ovarian Hyperstimulation Utilizing Insights From In Vitro Maturation Therapy." Journal of Assisted Reproduction and Genetics, 2014.
  16. Rose BI. "The Potential for Letrozole Use in Priming In Vitro Maturation Cycles." Facts, Views and Vision in ObGyn, 2014.
  17. Rose BI, Laky DC. "Polar Body Fragmentation in IVM Oocytes Is Associated With Impaired Fertilization and Embryo Development." Journal of Assisted Reproduction and Genetics, 2013.
  18. Rose BI, Laky DC. "A Comparison of the Cook Single Lumen Immature Ovum IVM Needle to the Steiner-Tan Pseudo Double Lumen Flushing Needle for Oocyte Retrieval for IVM." Journal of Assisted Reproduction and Genetics, 2013.
  19. Pasqualotto EB, Agarwal A, Sharma RK, Rose BI, and colleagues. "The Effect of Oxidative Stress in Follicular Fluid on the Outcome of Assisted Reproductive Procedures." Fertility and Sterility, 2004.
  20. Rose BI. "Ovarian Drilling in Infertile Women With Polycystic Ovary Syndrome." Journal of the American Association of Gynecologic Laparoscopy, 1996.
  21. Rose BI. "Pregnancy in Women Under 35 With Elevated Early Follicular Phase Follicle-Stimulating Hormone Levels." Journal of Reproductive Medicine, 1996.
  22. Rose BI, Scott B. "Sperm Motility, Morphology, Hyperactivation, and Ionophore-Induced Acrosome Reactions After Overnight Incubation With Mycoplasma Species." Fertility and Sterility, 1994.
  23. Rose BI. "The Use of a Single Intrauterine Insemination of Defrosted Cryopreserved Sperm for Therapeutic Donor Insemination." International Journal of Fertility, 1994.
  24. Rose BI. "A Conservative Low-Cost Superovulation Regimen." International Journal of Fertility, 1992.
  25. Rose BI, Koos RD. "The Effect of Human Follicular Fluid in Endothelial Cells: Proliferation and DNA Synthesis." Biology of Reproduction, 1988.
Book Chapter

Rose BI. "Avoidance of Severe Ovarian Hyperstimulation With IVM Treatment." In Development of In Vitro Maturation for Human Oocytes: Natural and Mild Approaches to Clinical Infertility Treatment. Springer, 2017.

Medical Abstracts and Research Grants

Dr. Rose's abstracts have addressed sperm preparation, oxidative stress, embryo development, endometrial receptivity, IVM, and reproductive surgery.

His funded research has included studies examining sperm selection and the effect of mycoplasma on sperm function.

What This Means for You

Credentials You Can Verify. Care You Can Trust.

Our physicians' research records matter because they strengthen the decisions we make with you. Their work gives us a deeper base for reviewing your history, comparing treatment options, and explaining why a particular next step may or may not make sense.

01.

Research Behind the Plan

Our physicians have not only read fertility research. They have published it, presented it, and participated in clinical studies that examined questions patients face during treatment.

That experience helps us look more closely at your diagnosis, previous response, and available options before recommending what comes next.

02.

Experience With Complex Cases

Some patients come to us before their first fertility treatment. Others arrive after unsuccessful IVF, pregnancy loss, reproductive surgery, or a diagnosis that has made the path forward less clear.

Our experience across IVF, reproductive surgery, egg and embryo development, implantation, and fertility preservation helps us consider the full picture.

03.

Clear Reasons Behind Our Recommendations

More treatment is not always better. A test, medication, or procedure should have a useful purpose in your case.

We will explain why we are recommending an option, what the evidence says, where its limits are, and whether another path may also be reasonable.

Your Next Step Starts Here

Bring Your Questions to Brown Fertility

You may be preparing for your first fertility evaluation, deciding whether to begin IVF, or trying to understand why earlier treatment did not work.

Bring us your history, your records, and the questions that have not been answered clearly. We will look at the full picture, talk through the reasoning behind your options, and help you understand what the next step may realistically involve.

Meet Our Physicians Why This Matters